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Minimum inhibitory concentrations (MIC, μg·mL -1 ) were tested against a panel of strains, including Streptococcus salivarius DA547, Streptococcus oralis <t>DA1241,</t> Streptococcus gordonii ATCC10558, Bacillus subtilis 168, Staphylococcus aureus ATCC29213, methicillin-resistant Staphylococcus aureus 544, methicillin-resistant Staphylococcus aureus 103, and Streptococcus pneumonia ATCC49619. Acetylated products (RTC-A and DAPG) consistently exhibited enhanced antimicrobial activity compared to their unacetylated precursors (preRTC-A and PG). G+ strains: Gram-positive strains. The relevant source data are provided as a Source Data file.
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Minimum inhibitory concentrations (MIC, μg·mL -1 ) were tested against a panel of strains, including Streptococcus salivarius DA547, Streptococcus oralis <t>DA1241,</t> Streptococcus gordonii ATCC10558, Bacillus subtilis 168, Staphylococcus aureus ATCC29213, methicillin-resistant Staphylococcus aureus 544, methicillin-resistant Staphylococcus aureus 103, and Streptococcus pneumonia ATCC49619. Acetylated products (RTC-A and DAPG) consistently exhibited enhanced antimicrobial activity compared to their unacetylated precursors (preRTC-A and PG). G+ strains: Gram-positive strains. The relevant source data are provided as a Source Data file.
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Minimum inhibitory concentrations (MIC, μg·mL -1 ) were tested against a panel of strains, including Streptococcus salivarius DA547, Streptococcus oralis DA1241, Streptococcus gordonii ATCC10558, Bacillus subtilis 168, Staphylococcus aureus ATCC29213, methicillin-resistant Staphylococcus aureus 544, methicillin-resistant Staphylococcus aureus 103, and Streptococcus pneumonia ATCC49619. Acetylated products (RTC-A and DAPG) consistently exhibited enhanced antimicrobial activity compared to their unacetylated precursors (preRTC-A and PG). G+ strains: Gram-positive strains. The relevant source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Evolutionary repurposing of a metabolic thiolase complex enables antibiotic biosynthesis

doi: 10.1038/s41467-026-68910-6

Figure Lengend Snippet: Minimum inhibitory concentrations (MIC, μg·mL -1 ) were tested against a panel of strains, including Streptococcus salivarius DA547, Streptococcus oralis DA1241, Streptococcus gordonii ATCC10558, Bacillus subtilis 168, Staphylococcus aureus ATCC29213, methicillin-resistant Staphylococcus aureus 544, methicillin-resistant Staphylococcus aureus 103, and Streptococcus pneumonia ATCC49619. Acetylated products (RTC-A and DAPG) consistently exhibited enhanced antimicrobial activity compared to their unacetylated precursors (preRTC-A and PG). G+ strains: Gram-positive strains. The relevant source data are provided as a Source Data file.

Article Snippet: The following indicator strains were used: Streptococcus salivarius DA547, Streptococcus oralis DA1241, Streptococcus gordonii ATCC 10558, Bacillus subtilis 168, Staphylococcus aureus ATCC 29213, Methicillin-resistant Staphylococcus aureus 544, Methicillin-resistant Staphylococcus aureus 103 and Streptococcus pneumonia ATCC 49619.

Techniques: Activity Assay